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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP3K12
All Species:
7.58
Human Site:
S686
Identified Species:
13.89
UniProt:
Q12852
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q12852
NP_006292.2
859
93219
S686
G
T
G
R
E
G
T
S
G
R
G
G
S
R
A
Chimpanzee
Pan troglodytes
XP_509099
871
93967
E697
S
P
G
G
A
K
G
E
P
P
P
P
V
G
P
Rhesus Macaque
Macaca mulatta
XP_001105474
890
96134
S716
G
T
G
R
E
G
T
S
G
R
G
G
S
R
A
Dog
Lupus familis
XP_857182
860
93116
A686
G
T
G
R
E
G
T
A
G
R
G
G
S
R
A
Cat
Felis silvestris
Mouse
Mus musculus
Q60700
888
96066
T713
E
G
V
G
L
L
G
T
G
R
E
G
T
A
G
Rat
Rattus norvegicus
Q63796
888
96289
G717
L
L
G
T
G
R
E
G
T
T
G
R
G
G
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422689
966
107967
N772
M
E
E
E
D
F
S
N
C
T
S
A
S
A
L
Frog
Xenopus laevis
A7J1T0
961
107551
S782
T
G
G
E
Q
F
S
S
L
K
A
A
V
G
V
Zebra Danio
Brachydanio rerio
NP_996977
856
94429
V674
R
E
E
G
P
G
A
V
R
L
P
R
G
S
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q95UN8
1161
128942
A918
A
E
D
E
D
A
V
A
A
E
V
D
T
A
D
Honey Bee
Apis mellifera
XP_397605
895
101116
N704
V
S
E
I
I
N
A
N
R
L
I
S
S
I
D
Nematode Worm
Caenorhab. elegans
O01700
928
103465
P733
S
R
A
R
S
P
T
P
Y
D
N
D
F
E
N
Sea Urchin
Strong. purpuratus
XP_795085
943
105022
M757
R
L
G
G
T
D
V
M
G
L
K
S
S
Y
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
95.7
95.2
97.4
N.A.
92.5
91.7
N.A.
N.A.
52.3
51.8
65.4
N.A.
24
38.4
29
38.6
Protein Similarity:
100
95.8
95.6
98.5
N.A.
93.8
93.1
N.A.
N.A.
62.5
63.1
74
N.A.
38.4
52.8
44.9
52.8
P-Site Identity:
100
6.6
100
93.3
N.A.
20
13.3
N.A.
N.A.
6.6
13.3
6.6
N.A.
0
6.6
13.3
20
P-Site Similarity:
100
6.6
100
100
N.A.
33.3
20
N.A.
N.A.
26.6
33.3
13.3
N.A.
20
20
13.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
8
0
8
8
16
16
8
0
8
16
0
24
24
% A
% Cys:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% C
% Asp:
0
0
8
0
16
8
0
0
0
8
0
16
0
0
16
% D
% Glu:
8
24
24
24
24
0
8
8
0
8
8
0
0
8
0
% E
% Phe:
0
0
0
0
0
16
0
0
0
0
0
0
8
0
0
% F
% Gly:
24
16
54
31
8
31
16
8
39
0
31
31
16
24
8
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
8
8
0
0
0
0
0
8
0
0
8
8
% I
% Lys:
0
0
0
0
0
8
0
0
0
8
8
0
0
0
0
% K
% Leu:
8
16
0
0
8
8
0
0
8
24
0
0
0
0
8
% L
% Met:
8
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
8
0
16
0
0
8
0
0
0
8
% N
% Pro:
0
8
0
0
8
8
0
8
8
8
16
8
0
0
8
% P
% Gln:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
16
8
0
31
0
8
0
0
16
31
0
16
0
24
0
% R
% Ser:
16
8
0
0
8
0
16
24
0
0
8
16
47
8
16
% S
% Thr:
8
24
0
8
8
0
31
8
8
16
0
0
16
0
0
% T
% Val:
8
0
8
0
0
0
16
8
0
0
8
0
16
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
8
0
0
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _